This resource equips home-based primary care (HBPC) providers with practical, evidence-informed strategies to identify, assess, and mitigate caregiver burden. It provides validated tools, standardized workflows, community-based integration guidance, and billing essentials to support clinicians in promoting safer, more sustainable caregiving environments. Home-based care models significantly reduce emergency department utilization, unnecessary hospitalizations, and caregiver burnout through proactive assessment, timely intervention, and high-touch longitudinal support. Because caregiver well-being directly impacts a patient’s ability to remain safely at home, effectively addressing caregiver burden is a core component of home-based care quality and risk-reduction strategies.